Exposure–Response Relationship of Tranexamic Acid in Cardiac Surgery
نویسندگان
چکیده
منابع مشابه
Tranexamic acid in paediatric cardiac surgery.
BACKGROUND & OBJECTIVES Antifibrinolytic agents are used commonly in adult cardiac surgery to reduce postoperative blood loss. Paucity of literature on the use of a newer antifibrinolytic agent tranexamic acid (TA) in children undergoing cardiac surgery promoted us to conduct this study in children with cyanotic heart disease. METHODS One hundred and twenty consecutive children with cyanotic ...
متن کامل1344159 - Pharmacokinetics of Tranexamic Acid in Patients Undergoing Cardiac Surgery
Introduction: Tranexamic acid (TXA) is routinely used during cardiac surgical procedures involving cardiopulmonary bypass (CPB) in order to reduce blood loss [1]. Although the optimum dose of TXA has been a subject of debate, a dosing regimen also sometimes referred to as the BART dose remains a popular choice for high-risk cardiac surgery [2]. The pharmacokinetics of TXA during the perioperati...
متن کاملAn anti-inflammatory role for tranexamic acid in cardiac surgery?
Pro- and anti-inflammatory cytokines are elevated after cardiac surgery. The control of the release of these major paracrine proteins is becoming clearer and they have been shown to be involved in the activation of the coagulation/fibrinolysis pathway, among other cascades. The association of a predominance of pro-inflammatory cytokines with morbidity in some patients, particularly following ca...
متن کاملHemostatic effects of tranexamic acid and desmopressin during cardiac surgery.
BACKGROUND Desmopressin-induced release of tissue plasminogen activator from endothelial cells may explain the absence of its hemostatic effect in patients undergoing cardiac surgery. Prior administration of the antifibrinolytic drug tranexamic acid might unmask such an effect, and combination therapy might thereby improve postoperative hemostasis. METHODS AND RESULTS A double-blinded design ...
متن کامل[Tranexamic acid in orthopedic surgery].
Perioperative bleeding may require blood transfusions, which are sometimes not without complications and risks, with the subsequent increase in health care costs. Among other prevention methods, treatment with tranexamic acid (ATX) has shown to be effective in reducing surgical blood loss, especially in the immediate postoperative period. In this regard, studies evaluating ATX in orthopedic sur...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2020
ISSN: 0003-3022,1528-1175
DOI: 10.1097/aln.0000000000003633